Clinical Studies:

DRVS Report 2

Early Vitrectomy for Severe Vitreous Hemorrhage in Diabetic Retinopathy

Summarized by Kyle Kovacs, MD (Weill Cornell Medicine Department of Ophthalmology)

Citation: Early vitrectomy for severe vitreous hemorrhage in diabetic retinopathy. Two-year results of a randomized trial. Diabetic Retinopathy Vitrectomy Study report 2. The Diabetic Retinopathy Vitrectomy Study Research Group. Arch Ophthalmol. 1985 Nov;103(11):1644-52.

Key Points

  • Compared early vitrectomy with conventional management (observation with later vitrectomy after 1 year) in recent severe diabetic vitreous hemorrhage (visual acuity 5/200 or less for at least 1 month)
  • There were significantly more patients who achieved good final visual acuity outcomes (10/20 or better) with early vitrectomy compared with observation/delayed vitrectomy (25% versus 15%)
  • At 2 years of follow-up there were significantly more Type 1 diabetics who achieved good visual acuity outcomes (10/20 or better) with early vitrectomy compared with observation/delayed vitrectomy (36% versus 12%). There was no significant difference in Type 2 diabetics.
  • Objective

    To compare outcomes of early vitrectomy compared with observation/delayed vitrectomy in patients with severe vitreous hemorrhage in diabetic retinopathy


  • STUDY DESIGN

    Randomized, multicenter, interventional clinical trial DRVS sites

  • Duration

    24 months


STUDY SUBJECTS



RANDOMIZATION SCHEME AND INTERVENTIONS

Randomized 1:1

(a) Early vitrectomy

(b) Deferral of vitrectomy (could be performed at 1 year)


RESULTS

Study population


Visual acuity end-points


Recurrent Vitreous Hemorrhage


Exploratory Outcome- DME


Adverse events


CONCLUSIONS